Financial information

First Busey: March 2022 Investor Presentation

1Q22 QUARTERLY

EARNINGS

EXTRA CHARGE

April 26, 2022

Special note regarding forward-looking statements

Statements made herein, other than those relating to historical financial information, may be deemed to be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 with respect to financial condition, results of operations, plans , objectives, future performance , and business of the Company. avant-garde statements, which may be based on beliefs, expectations and assumptions of the Company’s management, as well as information currently available to management, are generally identifiable by the use of words such as “believe”, “expect”, “anticipate”, “plan”, “intend”, “estimate”, “may”, “will”, “would”, “could”, “should”, or other similar expressions. In addition, all statements in this document, including forward-looking statements, speak only as of the date on which they are made, and the Company undertakes no obligation to update any statement in light of new information or future events. A number of factors, many of which are beyond the Company’s ability to control or predict, could cause actual results to differ materially from those announced by the Company.ard-

research statements. These factors include, among others, the following: (i) the strength of the local, state, national and international economy (including the effects of inflationary pressures and supply chain constraints); (ii) the economic impact of any future terrorist threat or attack, disease or generalized pandemic (including the coronavirus disease 2019 pandemic), or otherwise adverse external events that could cause economic deterioration or credit market instability (including the invasion of Russia of Ukraine); (iii) changes in state and federal governmental laws, regulations and policies regarding the Company’s terms and conditions Business; (iv) changes in accounting policies and practices; (v) changes in the Company’s interest rates and prepayment ratesyes assets (including the impact of the phasing out of the London Inter-bank Offered Rate); (vi) increased competition in the financial services industry and inability to attract new customers; (vii) changes in technology and the ability to develop and maintain secure and reliable electronic systems; (viii) loss of key officers or associates; (ix) changes in consumer spending; (X)

unexpected results of current and/or future acquisitions, which may include the failure to realize the anticipated benefits of any acquisition and the possibility that transaction costs will be higher than expected; (xi) unexpected results of existing or new litigation involving the Company; and (xii) the economic impact of extreme weather events such as tornadoes, hurricanes, floods and blizzards. These risks and uncertainties should be considered when evaluating forward-looking statements and undue reliance should not be placed on such statements. Additional information concerning the Company and its activity, including additional factors that could materially affect its financial results, is included in the Company’s filings withe Securities and Exchange Commission.

Non-GAAP financial information

This document contains certain financial information determined by methods other than GAAP. Management uses these non- GAAP measures, together with related GAAP measures, in analyzing the Company’s performance and in making business decisions, as well as comparing with the Company’s peers. The Company believes that the adjusted measures are useful for investors and management to understand the effects of certain one-time non-interest items and provide additional perspective on the Company performance over time.

A reconciliation to what management believes to be the most directly comparable GAAP financial measuresmore precisely, net interest income, total non-interest income, net gains and losses on securities and total non-interest expense in the case of pre-

funded net income, adjusted net income before funding, net income before funding to average assets and adjusted net income before funding to average assets; net income in the case of adjusted net income, adjusted diluted earnings per share, adjusted return on average assets, return on tangible average equity and adjusted return on tangible common equity; net interest income in the case of adjusted net interest income and adjusted net interest margin; net interest income, total non-interest income and total non-interest expense in the case of adjusted non-interest expense, basic adjusted expense, efficiency rate, adjusted efficiency rate and adjusted base efficiency rate; total equity in the case of yourngible book value per ordinary share; total assets and total equity in the case of tangible ordinary shares and tangible ordinary shares equity to tangible assets; portfolio loans in the case of base loans and base loans to portfolio loans; total deposits in the case of core deposits and core deposits to total deposits; and portfolio loans and total deposits in the case of core loans to core deposits

appears below.

This non-GAAP information has inherent limitations and is unaudited. They should not be considered in isolation or as a substitute for results of operations reported in accordance with GAAP, and they are not necessarily comparable to non-GAAP performance measures that may be reported by other companies. The tax-relevant figures included in this non-GAAP information are based on estimated statutory rates or effective rates, as applicable.

Contents

Introducing First Busey Corporation (BUSE)

5

Important professions for innovative solutions

6

Investment Highlights

7

Experienced management team

8

Strong regional operating model

9

High quality and growing loan portfolio

ten

First level basic deposit deductible

11

Diversified and significant sources of commission income

12

Fully integrated wealth management platform

13

Wealth management business growth

14

Scalable platform of payment technology solutions

15

Growth of FirstTech and Expansion of Services

16

Net interest margin

17

Targeted spending control

18

Ongoing investment in enterprise-wide technology

19

Balance sheet of the fortress

20

Solid capital foundation

21

Impeccable credit quality

22

Reserve supports credit and growth profile

23

Balanced, low-risk, short-term investment portfolio

24

Review of quarterly results

25

Earnings return

26

Environmental, social and governance responsibility

27

Appendix: Detail of loan portfolio, use of non-GAAP financial information

28

Introducing First Busey Corporation (BUSE)

150+ year old financial institution headquartered in CHAMPAIGN, IL

Unwavering focus on 4 pillars:

ASSOCIATES, CUSTOMERS, COMMUNITIES AND SHAREHOLDERS

Regional operating model serving 4 regions: NORTHERN, CENTRAL, GATEWAY, FLORIDA

in millions of dollars

2020

2021

2022 cumulative since the beginning of the year

Total assets

Total loans (excluding HFS) Total deposits

Total NPA Equity/NIM Assets

$10,544 6,814 8,678 1,270

$12,860 7,189 10,769 1,319

$12,568 7,273 10,592 1,218

0.27% 3.03% 1.75%

0.17% 0.13%

2.49% 2.45%

Adj. PPNR ROAA (1) Adj. ROAA (1)

1.35% 1.26%

1.06%

1.15% 0.93%

Adj. ROATCE (1)

12.47%

14.40% 13.02%

Market capitalization

$1.32 billion

$30

$28

Price per share

$23.75

Dividend yield

3.87%

$26

$24

$22

$20

March 21st

Jun-21

Sep 21

(1) Non-GAAP calculation, see Appendix (2) Market data for BUSE updated to close 04/25/22 (3) Based on consensus median FY2022 net income of hedge analysts as of 25 /04/22

AMONG THE BEST

Price/TBV

1.55x

Price/NTM (3)

10.8x

December 21

March 22